![]() ![]() ![]() Tricyclic antidepressants, such as amitriptyline and nortriptyline (Pamelor).Bupropion (Zyban, Wellbutrin SR, Wellbutrin XL), an antidepressant and tobacco-addiction medication.Serotonin and norepinephrine reuptake inhibitors (SNRIs), antidepressants such as desvenlafaxine (Pristiq), levomilnacipran (Fetzima), milnacipran (Savella), duloxetine (Cymbalta, Drizalma Sprinkle) and venlafaxine (Effexor XR).Selective serotonin reuptake inhibitors (SSRIs), antidepressants such as citalopram (Celexa), fluoxetine (Prozac), fluvoxamine (Luvox), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle) and sertraline (Zoloft).The drugs and supplements that could potentially cause serotonin syndrome include: Illicit drugs and dietary supplements also may be associated with the condition. It may also occur if you take an antidepressant with an opioid pain medication.Īnother cause of serotonin syndrome is intentional overdose of antidepressant medications.Ī number of over-the-counter and prescription drugs may be associated with serotonin syndrome, especially antidepressants. Serotonin plays a role in regulating the digestive process, blood flow and breathing.Īlthough it's possible that taking just one drug that increases serotonin levels can cause serotonin syndrome in some people, this condition occurs most often when people combine certain medications.įor example, serotonin syndrome may occur if you take an antidepressant with a migraine medication. Other nerve cells in the body, primarily in the intestines, also produce serotonin. Typically, nerve cells in the brain and spinal cord produce serotonin that helps regulate attention, behavior and body temperature. Excessive accumulation of serotonin in the body creates the symptoms of serotonin syndrome. ![]()
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